|
KMID : 0356820180340020011
|
|
Korean Journal of Head & Neck Oncology
2018 Volume.34 No. 2 p.11 ~ p.15
|
|
|
The treatment outcome of T2 laryngeal squamous cell carcinoma in one institution with long term follow-up: Radiotherapy alone vs Chemoradiotherapy
|
|
Jin Sung-Min
Kim Jae-Gu
Park Kyeong-Suk
Chung Ik-Joo
Chung Woong-Ki
Lee Dong-Hoon
Lee Joon-Kyoo
Lim Sang-Chul
Yoon Tae-Mi
|
|
|
Abstract
|
|
|
Background/Objectives: The efficacy of radiotherapy alone versus chemoradiotherapy has been studied in patients with T2N0M0 laryngeal squamous cell carcinoma.
Materials & Methods: Thirty nine patients with newly diagnosed T2N0M0 laryngeal squamous cell carcinoma were treated with either radiotherapy(RT group, 66-70Gy) or chemoradiotherapy(CRT group, cisplatin based concurrent chemoradiation with or without 2 cycles induction chemotherapy including cisplatin, 5-FU± docetaxel / radiation therapy same with above mentioned). The mean follow-up was 73.5 months.
Results: The overall survival (OS), disease specific survival (DSS), disease free survival (DFS), and larynx preservation survival (LPS) at 5 years were 70%, 79%, 67%, and 71%. The complete response rate was 82.4% in RT group, and was 95.5% in CRT group. OS (57% vs 80%), DSS (69% vs 86%), DFS (52% vs 77%), and LPS (63% vs 77%) at 5 years were higher in CRT group than RT group, but it was not statistically significant. In subsite analysis, CRT group tends to improve DFS, compared to RT group, in glottic cancer (p=0.06). The toxicities were tolerable and no fatal case was observed in both groups.
Conclusion: Chemoradiotherapy is effective as primary therapy for T2 laryngeal squamous cell carcinoma and showed manageable treatment induced toxicity.
|
|
|
KEYWORD
|
|
|
Head and neck neoplasms, Radiotherapy, Chemotherapy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|